HER2 positive rates are enriched amongst colorectal cancer brain metastases: a study amongst 1920 consecutive patients
نویسندگان
چکیده
منابع مشابه
Multicenter phase II study of lapatinib in patients with brain metastases from HER2-positive breast cancer.
PURPOSE Brain metastases develop in one third of patients with advanced HER2+ breast cancer. Effective therapy for patients with central nervous system (CNS) progression after cranial radiation is extremely limited and represents a major clinical challenge. Lapatinib, an epidermal growth factor receptor/HER2 inhibitor, was associated with regressions of CNS lesions in a small phase 2 trial. The...
متن کاملPatients with brain metastases from colorectal cancer are not condemned.
BACKGROUND Brain metastases (BMs) from colorectal cancer are rare (2-3%). They usually occur in advanced stages of the disease and their prognosis is poor. The aim of this study was to assess the impact of surgical resection of BMs from colorectal cancer in terms of overall survival. PATIENTS AND METHODS A retrospective bi-centric study included all patients with resected BMs from primary col...
متن کاملFormation of health-threatening behaviors amongst students: a qualitative study
Most high risk behavior form in adolescence. Unhealthy behavior such as unhealthy food habits, non physical activity, tobacco and alcohol consumption, and non safe sexual behavior establish in this critical period. Since the formation of the three domains of behavior can be influenced by behavioral, interpersonal, and environmental, exploring high-risk behaviors root among adolescents in socio ...
متن کامل64Cu-DOTA-trastuzumab PET imaging and HER2 specificity of brain metastases in HER2-positive breast cancer patients
BACKGROUND The purpose of this study was to determine whether brain metastases from HER2-positive breast cancer could be detected noninvasively using positron emission tomography (PET) with (64)Cu-1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid (DOTA)-trastuzumab. METHODS PET was performed on five patients with brain metastases from HER2-positive breast cancer, at 24 or 48 h after th...
متن کاملEvidence of PSMA Uptake in Brain Metastases in a Patient with Breast Cancer Her2/Neu Positive
Breast cancer is one of the most common causes of brain metastases resulting in a poor survival. The blood-brain barrier is an obstacle to the delivery of chemotherapeutics to the brain; treatment includes whole brain irradiation, stereotactic radio surgery or neurosurgery with whole brain radiation. The angiogenesis may be associated with metastasis independent of either invasion of normal tis...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Annals of Oncology
سال: 2018
ISSN: 0923-7534
DOI: 10.1093/annonc/mdy156